Snake oil originally came from China, where it is called ''shéyòu'' . There, it was used as a remedy for inflammation and pain in rheumatoid arthritis, bursitis, and other similar conditions. Snake oil is still used as a pain reliever in China. Fats and oils from snakes are higher in eicosapentaenoic acid than other sources, so snake oil was actually a plausible remedy for joint pain as these are thought to have inflammation-reducing properties. Snake oil is still sold in traditional Chinese pharmacy stores.
Snake fat also played a role in ancient Egyptian medicine, mixed with the fats of lion, hippopotamus, crocodile, tomcat, and Nubian ibex into a homogenous mass believed to cause bald men to grow hair.
on railroad gangs — involved in building the to link North America coast to coast — gave snake oil to Europeans with joint pain. When rubbed on the skin at the painful site, snake oil was claimed to bring relief. This claim was ridiculed by rival medicine salesmen, especially those selling patent medicines. In time, snake oil became a generic name for many compounds marketed as s or miraculous remedies, whose ingredients were usually secret, unidentified, or mis-characterized — and mostly inert or ineffective, although the placebo effect might provide some relief for whatever the problem might have been.
Patented snake oil remedies actually originated in England, where a patent was granted to Richard Stoughton's Elixir in 1712. Since there was no Federal regulation in the USA concerning safety and effectiveness of drugs until the 1906 Food and Drugs Act, and various medicine salesmen or manufacturers seldom had enough skills in analytical chemistry to analyze the contents of snake oil, it became the archetype of hoax. American snake fats do not have EPA contents as high as those of the Chinese water snake. The American snake oils were not effective in relieving pain like the original Chinese snake oil — further promoting the hoax stereotype.
The snake oil peddler became a stock character in Western movies: a travelling "doctor" with dubious credentials, selling some medicine with boisterous marketing hype, often supported by evidence, typically bogus. To enhance sales, an accomplice in the crowd would often "attest" the value of the product in an effort to provoke buying enthusiasm. The "doctor" would prudently leave town before his customers realized that they had been cheated. This practice is also called "grifting" and its practitioners "".
The practice of selling dubious remedies for real ailments still occurs today, albeit with some updated marketing techniques. Claims of cures for chronic diseases , for which there are reputedly only symptomatic treatments available from mainstream medicine, are especially common. The term ''snake oil peddling'' is used as a derogatory term to describe such practices.
An alternate theory for the origins of the term "snake oil" is that it was a corruption of "Seneca oil". The , a tribe in the Eastern United States, were known to use petroleum from natural seeps as a liniment for skin ailments. However, are known to have used rattlesnake fat and the herb snakeroot for various purposes.
Composition of snake oil
The composition of snake oil medicines varies markedly between products.
Snake oil sold in San Francisco's Chinatown in 1989 was found to contain:
* 75% unidentified carrier material, including camphor
* 25% oil from Chinese water snakes, itself consisting of:
** 20% eicosapentaenic acid - an derivative
** 48% myristic acid
** 10% stearic acid
** 14% oleic acid
** 7% linoleic acid plus arachidonic acid
The Chinese water snake is the richest known source of EPA, the starting material the body uses to make the series 3 prostaglandins. These prostaglandins are the biochemical messengers which control some aspects of inflammation, rather like aspirin which also affects the prostaglandin system. Like essential fatty acids, EPA can be absorbed through the skin. Salmon oil, the next best source, contains 18% EPA. Rattlesnake oil contains 8.5% EPA.
''Stanley's snake oil'' – produced by Clark Stanley, the "Rattlesnake King" – was tested by the federal government in 1917. It was found to contain:
* mineral oil
* 1% fatty oil
Given Dr. Richard Kunin's 1989 analysis, it appears that the Chinese snake oil made from Chinese water snakes is very high in EPA. This substance is known to be a pain reliever, as EPAs are absorbed through the skin and are the parent of the series 3 prostaglandins which inhibit the production of pro-inflammatory series 2 prostaglandins, and the Chinese snake oil products may contain up to 4% of it. Snake oil does not have the dubious reputation in China that it has in the US and elsewhere in the Western world, and it is used widely in traditional Chinese medicine. However, it is not seen as a in China either; there it is used only as relief for arthritis and joint pain.
From a purely pharmacochemical perspective, it is likely that the genuine Chinese snake oil is not fraudulent, at least for its intended purpose, since EPA indeed is an effective anti-inflammatory agent. On the other hand, American products made from rattlesnake fats, which have at most 1/3 of the EPA concentration of ''Enhydris chinensis'' fat, are likely to have been inferior or even useless for similar purposes because of their lower or even nonexistent anti-inflammatory contents — Stanley's snake oil contains no EPA at all. 19th century snake oil peddlers and apothecarians seldom had any serious knowledge of chemistry or pharmacology. It is likely that they did not understand the action mechanism of the Chinese product, or even know its functional ingredient. Instead of analyzing and reverse engineering the authentic remedy, they tried to imitate it with unimpressive results. Such inferior or even fraudulent products gave snake oil the reputation it has today.
; Poppy : W. C. Fields's film about a western frontier American snake oil salesman complete with a surreptitious crowd accomplice. His demonstration from the back of a buckboard of a miraculous cure for hoarseness ignited a comic purchasing frenzy.
; 's Pete's Dragon : The greedy "Doc" Terminus, played by Jim Dale, gave a testament to the persuasive power of the snake oil salesman. Dealing with a crowd of people he had conned on a prior visit, Terminus turns them from angry vengeance-seekers to believers once more, paying top dollar for Terminus' products despite their previous ineffectiveness.
; : Mark Twain presents Aunt Polly as a true believer in various sorts of snake oil, though not always in the form of an alleged medicine. She also adopted cold showers as a cure-all at one point in Tom's childhood. For a time she insisted that Tom Sawyer take every day, simply because she thought it would be good for him, until Tom gave some to Peter the housecat, who reacted to the dose with extreme agitation. After seeing the cat vanish in a frenzy out the window, Aunt Polly no longer forced Tom to take pain killers. .
; Say Say Say's music video : In a more modern appearance of grifting in pop-culture, the collaboration of Paul McCartney and Michael Jackson in 1983 produced a music video for ''Say Say Say'' which depicts McCartney as the salesman selling a dubious strength elixir from the back of a truck and Jackson as his accomplice amongst the audience.
; Beachcomber : Many of J. B. Morton's books and radio programs included short spoof advertisements for "Snibbo" a fictional treatment allegedly tackling various unlikely human conditions.
English musician and comedy writer Vivian Stanshall satirized a miracle cosmetic as "Rillago—the great ape repellent"